Tridax Procumbens Leaf Extract Mitigates Cardiac Oxidative Stress in Fructose-induced Hypertensive Male Wistar Rat

Oluwadunsin Dorcas Aina; Shehu-tijani Toyin Shittu; Grace Olufunmilayo Isehunwa; Hussein Mofomosara Salahdeen; Abdulrasak Akinola Alada.

doi:10.5455/jrtm.2025-249990

J. res. tradit. med. 2025; 11(1): 1-10

doi: 10.5455/jrtm.2025-249990

Tridax Procumbens Leaf Extract Mitigates Cardiac Oxidative Stress in Fructose-induced Hypertensive Male Wistar Rat

Oluwadunsin Dorcas Aina, Shehu-tijani Toyin Shittu, Grace Olufunmilayo Isehunwa, Hussein Mofomosara Salahdeen, Abdulrasak Akinola Alada..

Abstract
Background: Cardiac oxidative stress is associated with hypertension induced by fructose, and studies have documented the antioxidant activities of Tridax procumbens (TP). However, data on the impact of TP on fructose-induced hypertension are scarce. Therefore, the effect of the ethanol extract of TP leaf (ELETP) was studied. Methods: Thirty-five male Wistar rats (200 – 250 g) were grouped into 5 as I-V (n=7). Group I was the control, while hypertension was induced in groups II-V by drinking 10% fructose for 3 weeks. Thereafter, they were orally administered normal saline, 100mg/kg ELETP, 400 mg/kg ELETP, and a combination of 10 mg/kg Propranolol and 0.5 mg/kg of Prazosin, respectively, for another 4 weeks while still on fructose solution. Blood Pressure Variables [Systolic (SBP), Diastolic (DBP), Mean Arterial (MABP)] and Heart Rate (HR) were determined at the 3rd and 7th week non-invasively. Lipid profile and oxidative stress biomarkers [Malondialdehyde, Superoxide dismutase (SOD), and Catalase activities] in the plasma and cardiac tissue were determined at the end of the 7th week. Results: Group II had elevated SBP, DBP, MABP, and HR compared with the control, and these were reversed in Groups III-V. Elevated cholesterol and triglyceride levels induced by high-dose fructose were notably reduced after ELETP treatment. Cardiac Malondialdehyde levels increased while catalase activity decreased in II and reversed in III-V. Activity of SOD in the cardiac tissue was not different in II and III, while it increased in IV and V compared with I. Conclusion: Tridax procumbens mitigates fructose-induced hypertension, possibly through its antioxidant properties.

Key words: Tridax procumbens, Fructose, Hypertension, Oxidative stress, Lipid profile

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How to Cite this Article

Pubmed Style

Aina OD, Shittu ST, Isehunwa GO, Salahdeen HM, Alada. AA. Tridax Procumbens Leaf Extract Mitigates Cardiac Oxidative Stress in Fructose-induced Hypertensive Male Wistar Rat. J. res. tradit. med. 2025; 11(1): 1-10. doi:10.5455/jrtm.2025-249990

Web Style

Aina OD, Shittu ST, Isehunwa GO, Salahdeen HM, Alada. AA. Tridax Procumbens Leaf Extract Mitigates Cardiac Oxidative Stress in Fructose-induced Hypertensive Male Wistar Rat. https://www.tmjournal.org/?mno=249990 [Access: August 23, 2025]. doi:10.5455/jrtm.2025-249990

AMA (American Medical Association) Style

Aina OD, Shittu ST, Isehunwa GO, Salahdeen HM, Alada. AA. Tridax Procumbens Leaf Extract Mitigates Cardiac Oxidative Stress in Fructose-induced Hypertensive Male Wistar Rat. J. res. tradit. med. 2025; 11(1): 1-10. doi:10.5455/jrtm.2025-249990

Vancouver/ICMJE Style

Aina OD, Shittu ST, Isehunwa GO, Salahdeen HM, Alada. AA. Tridax Procumbens Leaf Extract Mitigates Cardiac Oxidative Stress in Fructose-induced Hypertensive Male Wistar Rat. J. res. tradit. med. (2025), [cited August 23, 2025]; 11(1): 1-10. doi:10.5455/jrtm.2025-249990

Harvard Style

Aina, O. D., Shittu, . S. T., Isehunwa, . G. O., Salahdeen, . H. M. & Alada., . A. A. (2025) Tridax Procumbens Leaf Extract Mitigates Cardiac Oxidative Stress in Fructose-induced Hypertensive Male Wistar Rat. J. res. tradit. med, 11 (1), 1-10. doi:10.5455/jrtm.2025-249990

Turabian Style

Aina, Oluwadunsin Dorcas, Shehu-tijani Toyin Shittu, Grace Olufunmilayo Isehunwa, Hussein Mofomosara Salahdeen, and Abdulrasak Akinola Alada.. 2025. Tridax Procumbens Leaf Extract Mitigates Cardiac Oxidative Stress in Fructose-induced Hypertensive Male Wistar Rat. JOURNAL OF RESEARCH IN TRADITIONAL MEDICINE, 11 (1), 1-10. doi:10.5455/jrtm.2025-249990

Chicago Style

Aina, Oluwadunsin Dorcas, Shehu-tijani Toyin Shittu, Grace Olufunmilayo Isehunwa, Hussein Mofomosara Salahdeen, and Abdulrasak Akinola Alada.. "Tridax Procumbens Leaf Extract Mitigates Cardiac Oxidative Stress in Fructose-induced Hypertensive Male Wistar Rat." JOURNAL OF RESEARCH IN TRADITIONAL MEDICINE 11 (2025), 1-10. doi:10.5455/jrtm.2025-249990

MLA (The Modern Language Association) Style

Aina, Oluwadunsin Dorcas, Shehu-tijani Toyin Shittu, Grace Olufunmilayo Isehunwa, Hussein Mofomosara Salahdeen, and Abdulrasak Akinola Alada.. "Tridax Procumbens Leaf Extract Mitigates Cardiac Oxidative Stress in Fructose-induced Hypertensive Male Wistar Rat." JOURNAL OF RESEARCH IN TRADITIONAL MEDICINE 11.1 (2025), 1-10. Print. doi:10.5455/jrtm.2025-249990

APA (American Psychological Association) Style

Aina, O. D., Shittu, . S. T., Isehunwa, . G. O., Salahdeen, . H. M. & Alada., . A. A. (2025) Tridax Procumbens Leaf Extract Mitigates Cardiac Oxidative Stress in Fructose-induced Hypertensive Male Wistar Rat. JOURNAL OF RESEARCH IN TRADITIONAL MEDICINE, 11 (1), 1-10. doi:10.5455/jrtm.2025-249990