E-ISSN 2455-3166
 

Original Research 


Pharmaceutico -Analytical evaluation of Mahagandhakam

Varsha Sumedhan, Gopinathan Nair Jai, Kiran Sarma.

Abstract
Background: Mahagandhakam is a formulation mentioned in the Grahani Roga Chikitsa (sprue like syndrome) of Bhaishajya Ratnavali which incorporates both ‘Parpati’(thin flakes of mercuric sulphide) and ‘Pottali’ ( consolidated form of mercuric sulphide) Kalpanas of Parada (mercury). In Rasasastra (branch of Ayurveda chemistry) Parpati Rasayanas are considered as the most effective preparations for the treatment of Grahani Roga (sprue like syndrome).

Aim: An attempt has been made to evaluate the pharmaceutical and analytical parameters of Mahagandhakam.

Materials & Methods: Mahagandhakam was prepared out of Parada (Mercury) Gandhaka (Sulphur), Jatipatra (Aril of Myristica fragrance Houtt), Jatiphala (seed of Myristica fragrance Houtt), Lavanga (Syzygium aromaticum Linn), Sinduvaradala (Vitex Negundo Linn), Nimbapatra (Azadirachta indica A), Elabeeja (Elettaria cardamom Linn), Muktasukti (shell of Mytilus margaratis Linn) and Tankana (Borax). The physical and chemical characteristics of the drug were analysed by XRD, XRF, SEM, TEM and ICP-MS technique

Observations: Mahagandhakam was prepared in a single Gaja Puta. The pH of the drug was 9.5 which indicated the alkalinity of the formulation. Calcium oxide was found to be the major ingredient and mercury was present only in 20.23 ppm levels. From these analytical data it can be assessed that the product contain more of calcium compounds rather than mercury and sulphur. As Mukta Sukti is basically CaCO3, on incineration, the CO2 portion may have escaped and the CaO part remained. The SEM and TEM analysis of the study drug indicates the reduction of particle size up to 200nm which may help in easy assimilation and absorption of drug in the body.

Conclusion: Mahagandhakam can be prepared by a single Puta (incineration). The analytical parameters suggest the presence of more calcium compound rather than Mercury and Sulphur.

Key words: ICP-MS, Mahagandhkam, Parpati Rasayana, SEM, TEM, XRD, XRF


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Varsha Sumedhan
Articles by Gopinathan Nair Jai
Articles by Kiran Sarma
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Sumedhan V, Jai GN, Sarma K. Pharmaceutico -Analytical evaluation of Mahagandhakam. J. res. tradit. med. 2018; 4(2): 58-69. doi:10.5455/JRTM.2018/875


Web Style

Sumedhan V, Jai GN, Sarma K. Pharmaceutico -Analytical evaluation of Mahagandhakam. http://www.tmjournal.org/?mno=875 [Access: July 08, 2020]. doi:10.5455/JRTM.2018/875


AMA (American Medical Association) Style

Sumedhan V, Jai GN, Sarma K. Pharmaceutico -Analytical evaluation of Mahagandhakam. J. res. tradit. med. 2018; 4(2): 58-69. doi:10.5455/JRTM.2018/875



Vancouver/ICMJE Style

Sumedhan V, Jai GN, Sarma K. Pharmaceutico -Analytical evaluation of Mahagandhakam. J. res. tradit. med. (2018), [cited July 08, 2020]; 4(2): 58-69. doi:10.5455/JRTM.2018/875



Harvard Style

Sumedhan, V., Jai, . G. N. & Sarma, . K. (2018) Pharmaceutico -Analytical evaluation of Mahagandhakam. J. res. tradit. med, 4 (2), 58-69. doi:10.5455/JRTM.2018/875



Turabian Style

Sumedhan, Varsha, Gopinathan Nair Jai, and Kiran Sarma. 2018. Pharmaceutico -Analytical evaluation of Mahagandhakam. JOURNAL OF RESEARCH IN TRADITIONAL MEDICINE, 4 (2), 58-69. doi:10.5455/JRTM.2018/875



Chicago Style

Sumedhan, Varsha, Gopinathan Nair Jai, and Kiran Sarma. "Pharmaceutico -Analytical evaluation of Mahagandhakam." JOURNAL OF RESEARCH IN TRADITIONAL MEDICINE 4 (2018), 58-69. doi:10.5455/JRTM.2018/875



MLA (The Modern Language Association) Style

Sumedhan, Varsha, Gopinathan Nair Jai, and Kiran Sarma. "Pharmaceutico -Analytical evaluation of Mahagandhakam." JOURNAL OF RESEARCH IN TRADITIONAL MEDICINE 4.2 (2018), 58-69. Print. doi:10.5455/JRTM.2018/875



APA (American Psychological Association) Style

Sumedhan, V., Jai, . G. N. & Sarma, . K. (2018) Pharmaceutico -Analytical evaluation of Mahagandhakam. JOURNAL OF RESEARCH IN TRADITIONAL MEDICINE, 4 (2), 58-69. doi:10.5455/JRTM.2018/875





Most Viewed Articles
  • Efficacy of Erand Sneha (Castor Oil) in the management of Amavata (Rheumatoid arthritis) with respect to its Sama Stage
    Gauridutt Mishra *, Darshana H Pandya
    J. res. tradit. med. 2017; 3(2): 28-35
    » Abstract

  • URAMARUNNU - A TRADITIONAL AYURVEDIC PAEDIATRIC PRACTICE
    INDU SABU, KRISHNA RAO SATHYA
    J. res. tradit. med. 2017; 3(3): 91-97
    » Abstract

  • Shashti Upakrama (Sixty Procedures) in the management of Vrana (Wound) - A Review
    Rajneesh V Giri
    J. res. tradit. med. 2017; 3(4): 109-116
    » Abstract

  • Concept of Chakshushya in the Materia Medica of Ayurveda
    Tarkeshwar Sukhadev Wankhade* , Pravin Raghunathrao Joshi, Suraj Laxmansingh Thakur, Mante G B
    J. res. tradit. med. 2017; 3(2): 55-63
    » Abstract

  • Pharmaceutico - Analytical Study of Shrugatakadi Taila using the concept of Taila Murchhana (Oil Processing)
    Juhi Ubale* , Anita Wanjari, Bharath Rathi, Dhirajsingh Rajput
    J. res. tradit. med. 2017; 3(2): 36-42
    » Abstract

  • Most Downloaded
  • URAMARUNNU - A TRADITIONAL AYURVEDIC PAEDIATRIC PRACTICE
    INDU SABU, KRISHNA RAO SATHYA
    J. res. tradit. med. 2017; 3(3): 91-97
    » Abstract

  • A Review on Smriti (Memory) and its Affiliates in Ayurveda
    Pallavi Ashok Ghadage, Niranjan Yethdaka, Narendra Trivedi
    J. res. tradit. med. 2017; 3(5): 143-150
    » Abstract

  • Prevention & Management of Autism – An Ayurvedic Perspective
    Brahm Dutt Sharma*, Khushal Chouhan
    J. res. tradit. med. 2016; 2(4): 117-121
    » Abstract

  • Application of Tantrayukti (Means of Interpreting Science) in Research Methodology
    Anil D. Avhad*, Manjiri Walinjkar, Hitesh A. Vyas, R.R. Dwivedi
    J. res. tradit. med. 2016; 2(3): 81-86
    » Abstract

  • Early Clinical Diagnosis of Fever (Jwara) in Children – A Case Study
    Jyothy Kothanath Bhaskaran*, Srihari Sheshagiri
    J. res. tradit. med. 2016; 2(6): 170-172
    » Abstract

  • Most Cited Articles
  • Fourier Transforms Infrared Spectroscopy Study on Shadguna Makaradhwaja - An Ayurvedic Mercurial Drug Compound
    Vaibhav Charde*, Kishor Patel, Rohit Gokarn, Dhirajsingh Rajput, Biswajyoti Patgiri, Pradeep Kumar Prajapati
    J. res. tradit. med. 2016; 2(4): 94-98
    » Abstract
    Cited : 3 times [Click to see citing articles]

  • Multiple Stage Surgical Approach along with Ksharasutra Therapy in the Management of High Anal Fistula (Bhagandara) [English]
    Alok Kumar*, P. Hemantha Kumar, Narinder Singh
    J. res. tradit. med. 2016; 2(2): 51-53
    » Abstract
    Cited : 1 time [Click to see citing article]

  • Wound Exudates and its Analogies – A Prognostic Indicator
    Rashmi Tenkalkote Mahesh, Sathish Heggade Siddalingaiah, Mithun Bhaskar Shetty, Narmada Magalam Gururajarao, Lalatendu Sekhar Panigrahy
    J. res. tradit. med. 2017; 3(4): 101-108
    » Abstract
    Cited : 1 time [Click to see citing article]

  • Literature Review of Suram(Fever) in Siddha Medicine
    Thayalini Thileepan
    J. res. tradit. med. 2018; 4(1): 21-25
    » Abstract » doi: 10.5455/JRTM.2018/298118
    Cited : 1 time [Click to see citing article]

  • Clinical Evaluation of Dashmularishta (Ayurvedic formulation) in Restoring Normal Health of Postpartum Females
    Manjari Dwivedi, J.L.N Sastry*, Rajiv K Rai, Sasibhushan Vedula
    J. res. tradit. med. 2016; 2(3): 56-61
    » Abstract
    Cited : 1 time [Click to see citing article]